ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0017.3-2 | Thyroid hormone action | ESPEYB17

3.2. Multiple mechanisms regulate H3 acetylation of enhancers in response to thyroid hormone

SM Praestholm , MS Siersbaek , R Nielsen , X Zhu , A Hollenberg , SY Cheng , L Grontved

To read the full abstract: PLoS Genet. 2020;16:e1008770.Præstholm et al. quantified by a genomics approach histone H3 acetylation – an epigenetic mark for DNase accessible chromatin – at thyroid hormone target gene enhancers to challenge the current model of genome binding action of T3 (type 1 action of thyroid hormone receptors (TR)) [1]. For this, they investigated genome-wide the liver of WT mice at hypothyroid and hyp...
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ey0015.3-13 | Thyroid stem cells | ESPEYB15

3.13 Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification

M Serra , KD Alysandratos , F Hawkins , KB McCauley , A Jacob , J Choi , IS Caballero , M Vedaie , AA Kurmann , L Ikonomou , AN Hollenberg , JM Shannon , DN Kotton

To read the full abstract: Development 2017;144:3879-3893Regenerative medicine techniques are being widely investigated for organs without regenerative capacity, such as lung. Whether pluripotent stem cell derived thyroid organoids will be used in the future as a regenerative medicine approach to treat hypothyroidism is unclear. In the context of an easily available, very cheap and non-in...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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